Tag: Health research
Watch how radio waves and strong magnets combine to create pictures of the inside of our bodies.
These awesome diagnostic tools, powered by strong superconducting magnets, save countless lives with their ability to pinpoint tumors and other abnormalities.
This sports and science mash up features new geeky games inspired by the cool things scientists study in high-field magnets.
A lot of the research conducted in powerful magnets ends up having a powerful effect on our day-to-day lives.
Using high-field MRI, researchers are working to improve recovery in stroke victims.
Physicist Felix Bloch developed a non-destructive technique for precisely observing and measuring the magnetic properties of nuclear particles.
Leon Cooper shared the 1972 Nobel Prize in Physics with John Bardeen and Robert Schrieffer, with whom he developed the first widely accepted theory of superconductivity.
Willem Einthoven invented a string galvanometer that could be used to directly record the electrical activity of the heart.
Luigi Galvani was a pioneer in the field of electrophysiology, the branch of science concerned with electrical phenomena in the body.
Chemist Paul Lauterbur pioneered the use of nuclear magnetic resonance (NMR) for medical imaging.
French physician Guillaume Benjamin Amand Duchenne invented a device that electrically stimulates muscles. The apparatus gave him new insight into neuromuscular disorders, earned him the epitaph of "father of electrotherapeutics," and entertained the courts of Europe.
If TV medical dramas have taught us anything, it's how to recognize the heart's characteristic peaks and valleys crawling across monitors in emergency rooms. These images represent the electrical activity of the beating heart as recorded by an electrocardiograph, a machine that revolutionized diagnostic cardiology and helped garner a Nobel Prize.
Many heads, hands and hearts contributed to the development of this lifesaving device.
Pack a sack lunch and load up! We're hitting the road to learn how this massive magnet tracks sodium moving through your brain.
What’s going on inside that brain of yours? Learn more about your brain, its parts and what they do, by building a brain Cerebrum hat!
This high-field EPR study of the H-Mn2+ content in the bacterium Deinococcus Radiodurans provides the strongest known biological indicator of cellular ionizing radiation resistance between and within the three domains of the tree of life, with potential applications including optimization of radiotherapy.
This work investigates a series of oxoiron complexes that serve as models towards understanding the mechanism of catalysis for certain iron-containing enzymes.
Insights into the structure and movement of T cell surface proteins could lead to new ways to fight cancers, infections and other diseases.
High-magnetic-field time-resolved electron magnetic resonance was used to probe the unusual manganese/iron complex that is believed to play a role in the disease-producing activity of tuberculosis “superbugs,” revealing a vacancy in the vicinity of the manganese that is believed to enable a target molecule to bind to the metal ion.
New instrumentation allows electron magnetic resonance experiments to be performed in the lab’s flagship 36 T Series-Connected Hybrid magnet, unlocking exceptionally high-resolution EMR spectra at the highest magnetic fields.
Protein oxidative damage is a common occurrence in a number of diseases, including cancer, neurodegenerative, and cardiovascular disease. Yet, little is known about its contribution to these illnesses. We developed a new technique, utilizing an infrared laser in combination with a mass spectrometer, to selectively identify sites of oxidation in complex protein mixtures. This sensitive and rapid platform may outperform current techniques and thus shed light on the involvement of oxidative damage in each of these diseases.
Precise determination of hemoglobin sequence and subunit quantitation from human blood for diagnosis of hemoglobin-based diseases.
Combining spatial imaging technology with ultrahigh performance FT-ICR mass spectrometry provides users with the unique ability to create tissue images of identified biomolecules. This technology will be applied to understand human health and disease.
A new Blood Proteoform Atlas maps 30,000 unique proteoforms as they appear in 21 different cell types found in human blood. The MagLab's 21 tesla FT-ICR mass spectrometer contributed nearly a third of the atlas' proteoforms.
New technique could lead to precise, personalized cancer diagnosis and monitoring.
Researchers used the MagLab to produce the first clarified map of KRAS proteins in colon cancer tumors. Twenty-eight additional forms of the KRAS protein were discovered, including a new form of the protein (called clipped-KRAS) that does not bind to the cell membrane, instead serving as a kind of on-off switch to regulate cell growth. These findings may help yield future cancer treatments.
Identification of toxic compounds in drinking water formed through disinfection reveals more than 3500 toxic, chlorinated species that can only be observed by the MagLab's high powered analytical instruments.
Scientists measured the first in vivo images of stimulated current within the brain using an imaging method that may improve reproducibility and safety, and help understand the mechanisms of action of electrical stimulation.
Combining high-field NMR with infrared microscopy, scientists learned more about how gas diffuses in a novel class of molecular sieves that could one day be used for gas separation.
Little is known about the path of metabolic waste clearance from the brain. Here, high-field magnetic resonance images a possible pathway for metabolic waste removal from the brain and suggests that waste clearance may be one reason why we sleep.
Magnetic Resonance Imaging (MRI) of mouse models for Alzheimer’s disease can be used to determine brain response to plaque deposits and inflammation that ultimately disrupt emotion, learning, and memory. Quantification of the early changes with high resolution MRI could help monitor and predict disease progression, as well as potentially suggest new treatment methods.
MRI scans taken after a stroke show brightness around the injury, the origins of which have been a long-standing and vexatious mystery for scientists. This work suggests these MRI signal changes result from fluid changes in glial cell volumes, results that could advance our ability to distinguish reversible and irreversible stroke events or provide a better understanding for other disorders such as Parkinson's, Alzheimer's, and mood or sleep disorders.
Using NMR, researchers determined a molecular model of a protein-polymer conjugate, providing new insights into how polymers can be used to make protein drugs more robust.
The causes of migraines are not well understood, with treatment limited to addressing pain rather than its origin. Research conducted with hydrogen MRI is attempting to identify the "migraine generator."
With unprecedented sensitivity and resolution from state-of-the-art magnets, scientists have identified for the first time the cell wall structure of one of the most prevalent and deadly fungi.
With advanced techniques and world-record magnetic fields, researchers have detected new MRI signals from brain tumors.
This new technique for mapping out atom placements in the active site of enzymes could unlock the potential for finding new therapeutics.
A new 17O solid-state NMR technique, employed on the highest-field NMR spectrometer in the world (the 36 T Series Connected Hybrid), identifies water molecules in different layers of a model membrane for the first time.
Chemists are rarely able to use oxygen NMR to determine molecular structures, since 17O is an extremely challenging nucleus to observe. This work provides a mechanism for obtaining a complete set of 17O NMR parameters for a glucose molecule, paving the way for researchers to consider 17O NMR as a new spectroscopic tool.
Combining high magnetic fields, specialized probes, and measurement techniques, this work adds the crucial 17O nucleus into the study of biomolecules like peptides, proteins, and enzymes.
Reuse of the MagLab's Ion Cyclotron Resonance facility data improved understanding of protein fragmentation and aided the design and release of new algorithms and software tools. This is representative of a new type of MagLab user: A Data User – who accesses MagLab data from public data repositories to advance independent research goals.
Evolutionary biologists reused FAIR data generated at the MagLab's NMR facility to model an RNA-binding protein in mammals dating back 160 million years and to explore how evolution and natural selection have influenced the structure of the protein. Their work suggests new strategies for improving our understanding of this protein, which could lead to improved therapies for neurodegenerative diseases like ALS.
Datasets of rat brain imaging can be difficult to compare due to the different conditions used to collect them. The Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) Facility participated in a multi-institution study to develop a standardized protocol for functional MRI rat brain datasets, work that will help data be reused effectively to yield new discoveries.
Research sheds new light on the formation of harmful structures that can lead to neurodegenerative diseases.
State-of-the-art ion cyclotron resonance magnet system offers researchers significantly more power and accuracy than ever before.
The National Science Foundation announces five-year funding grant for continued operation of the world’s most powerful magnet lab.
Finding could make pricey, massive scanners a thing of the past.
The visit marked the first time the Group of Senior Officials for Global Infrastructures has met in the United States.
35 highlights out of 423 reports representing the best of life sciences, chemistry, magnet science and technology, and condensed matter physics.
Findings clarify the role of sodium increase early in migraines and point to the region where symptoms may start.
Researchers at the National MagLab will study the role sodium plays in this painful disease and test treatments that could offer relief.
Enabled by a world-record instrument, the images convey vast amounts of data that could be useful in health and pharmaceutical research.
New insights challenge current understanding of how ion transport through some cell membranes works.
Tallahassee Company MagCorp to Partner with National MagLab.
Molecular architecture of fungal cell walls and the structural responses to stresses revealed in new paper.
The MagLab and the Bruker Corporation have installed the world’s first 21 tesla magnet for Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometry.
Improving technology for research of biomolecules and advancing our understanding of health and disease.
MagLab NMR Facility Director Rob Schurko was awarded the Vold Prize for his contributions to the field of solid-state NMR over the past 25 years.
"We're opening up the world at a molecular level to understand how these fires are going to impact us."
Researchers are working to characterize the virus’ envelope protein, or E protein, believed to be key to virus activity.
Researcher digs below the coronavirus's membrane in search of another layer of infection-causing proteins.
For membrane protein expert Tim Cross, solving the structure of a misunderstood protein put retirement on hold.
The virus that causes COVID-19 has thousands of potential drug targets. A global team is on a hunt for the best candidates.
A team of experts believes stem cells could be a route to a fast, effective therapy.
Borderline biology? Crossover chemistry? Scientists are working on the edge of their fields to learn how proteins police the walls of cells.
Scientists are working to understand the complex reactions that create nanocages, work that could help uncage new drug delivery and energy options.
How is nano science advancing door-to-door drug delivery, but on the cellular level?
What happens when a kid with ADHD sustains a concussion? Using high-field magnets, researchers are working to find out.
Using advanced MRI, a mechanical engineer tackles the question: "Why do you have these big fluid spaces in your head?"
Scientists are using powerful magnets to learn how to better detect, treat and track the second leading cause of death worldwide.
New research is a first step toward understanding how a certain protein may help tuberculosis bacteria survive.
MagLab researchers and doctors at the University of Florida are testing a new MRI technique that can deliver images of the lungs like never before
Used to perform complex chemical analysis, this magnet offers researchers the world's highest field for ion cyclotron resonance mass spectrometry.
It's freaking hard to examine proteins closely in their native habitat. With the help of very clever magnet instrumentation, University of Texas scientist Kendra Frederick is up for the challenge.
Andreas Neubauer took the extended stay option during his recent trip to the MagLab. After all, you can't rush art — especially when it's mixed with science.
Why are scientists putting a mouse in the MagLab's magnets? A scientist is developing an MRI technique to detect kidney disease that lights up the organs' metabolism.
ICR technology helps identify new kinds of hemoglobin abnormalities.
Looking for clues on climate change, a scientist digs up the dirt on peat from around the world.
Each day at work, Long, tackles the twin duties of providing administrative leadership for a growing program, and her own scientific research.
- Dynamic nuclear polarization
- Energy research
- Health research
- Life research
- Magnet technology
- Mass spectrometry
- Materials research
- NMR and MRI
- Postdocs and grad students
- Quantum computing
- Science & Art
- STEM education
- 100-tesla multi-shot magnet
- 32-tesla superconducting magnet
- 45-tesla hybrid magnet
- 900MHz magnet
- 36-tesla SCH
- 25-tesla split magnet
- 41-tesla resistive magnet
- 21-tesla ICR magnet
- 600 MHz 89 mm MAS DNP System