Research Interests: Dr. DeHart’s research interests focus on the characterization of intact protein forms (proteoforms) and novel post-translational modifications (PTMs) of key oncoproteins by targeted top-down mass spectrometry. Her group also employs a combination of global, targeted, quantitative, top-down, native, and crosslinking-based proteomic workflows to support RAS Initiative collaborative projects with the goal of better understanding (and inhibiting) RAS-dependent signaling in human cancer.
Research Interests: Prof. Fernandez’s current research interests include the field of metabolomics and the development of new ionization methods and ion mobility tools for probing composition and structure in complex molecular mixtures.
Research Interests: Current research projects in the Julian lab include the top-down analysis of proteins by radical-directed dissociation (RDD) to obtain both sequence and structural information. We also develop and apply methods for analyzing peptides with isomerized residues in complex biological samples, including protocols incorporating DIA, RDD, UVPD, ion mobility, and liquid chromatography.
Research Interest: The leach lab at the University of Georgia focuses its research activities on the determination of molecular structure by FTMS in the context of environmental health with emphasis areas ranging from the interaction of emerging contaminants with natural organic matter and biota in wetland ecosystems to how the metabolic profile of organisms is affected by environmental exposures. The primary goal of these wide-ranging activities is to enable a more detailed understanding of environmental interactions and make a positive impact on public health.
Research Interests: My primary research focus is on ion control and manipulation with RF ion guides and collision cells as well as precision mass measurement with electrodynamic and electrostatic ion traps.