Tag: NMR and MRI
Watch how radio waves and strong magnets combine to create pictures of the inside of our bodies.
Magnetic Resonance Imaging machines, commonly known as MRIs, are awesome diagnostic tools for medical applications and research. Relying on strong superconducting magnets, they save countless lives with their ability to visualize tumors and other medical abnormalities.
You've probably heard of people having MRIs, but what would fruits & veggies look like imaged by a powerful magnet? Try your hand at our new guessing game to put your mind to the test.
These awesome diagnostic tools, powered by strong superconducting magnets, save countless lives with their ability to pinpoint tumors and other abnormalities.
Follow us down this yellow brick road to learn how these deceptively small molecules conceal enormous potential for applications from carbon capture to data storage.
Pack a sack lunch and load up! We're hitting the road to learn how this massive magnet tracks sodium moving through your brain.
This research clarifies fundamental relationships between magnetism, superconductivity and the nature of the enigmatic “pseudogap state" in cuprate superconductors. The discovery provides an additional puzzle piece in the theoretical understanding of high-temperature superconductors - a key towards improving and utilizing these materials for technological applications.
The MagLab's 32 T all-superconducting magnet is now serving users at full field. An early experiment in the magnet identified an important milestone on the road to quantum computers.
In this study, researchers added a low concentration of the endohedral metallofullerene (EMF) Gd2@C79N to DNP samples, finding that 1H and 13C enhancements increased by 40% and 50%, respectively, at 5 teslas and 1.2 Kelvin.
The findings contribute to scientists' understanding of magnetic materials that could point the way to future applications.
High-magnetic-field time-resolved electron magnetic resonance was used to probe the unusual manganese/iron complex that is believed to play a role in the disease-producing activity of tuberculosis “superbugs,” revealing a vacancy in the vicinity of the manganese that is believed to enable a target molecule to bind to the metal ion.
Study of helium atoms at low temperatures illuminate extreme quantum effects that were earlier predicted.
Using the NMR techniques and ultra-low temperature facilities at the MagLab, atoms of a pure isotope of helium showed experimental signs of the Luttinger liquid theory, an exact quantum mechanical solution of interacting fermions in one-dimension.
Combining spatial imaging technology with ultrahigh performance FT-ICR mass spectrometry provides users with the unique ability to create tissue images of identified biomolecules. This technology will be applied to understand human health and disease.
Sunlight can chemically transform plastics from consumer plastic bags into complex chemical mixtures that leach into the ocean. Understanding the impact of plastic pollution requires advanced analytical techniques that can identify transformed plastic molecules in water samples, and requires instrumentation only available at the MagLab.
Scientists measured the first in vivo images of stimulated current within the brain using an imaging method that may improve reproducibility and safety, and help understand the mechanisms of action of electrical stimulation.
A new pH sensitive contrast agent for MR imaging has been developed that produces image contrast based on the local pH and that has great potential for use in living animals and medical diagnostics.
Combining high-field NMR with infrared microscopy, scientists learned more about how gas diffuses in a novel class of molecular sieves that could one day be used for gas separation.
Three variants of the coral species A cervicornis were found to have unique metabolic signatures that can be distinguished by NMR spectroscopy. Differing levels of the metabolite trimethylamine-N-oxide, an important compound that protects against nitrogen overload, can distinguish the three variants studied. Understanding how species vary metabolically, and how that translates to species survival in stressed environments, may help us to establish desirable traits that could help with restoration and other interventions.
Little is known about the path of metabolic waste clearance from the brain. Here, high-field magnetic resonance images a possible pathway for metabolic waste removal from the brain and suggests that waste clearance may be one reason why we sleep.
Magnetic Resonance Imaging (MRI) of mouse models for Alzheimer’s disease can be used to determine brain response to plaque deposits and inflammation that ultimately disrupt emotion, learning, and memory. Quantification of the early changes with high resolution MRI could help monitor and predict disease progression, as well as potentially suggest new treatment methods.
Magnetic resonance of cancer cell metabolism is a novel technique to discern between cancerous and normal liver cells, providing a promising approach for cancer stage progression imaging without the harmful exposure of radiation.
Non-alcoholic Fatty Liver Disease and its progression to more serious diseases will become the main cause for liver transplant in the next 5 years. Here, researchers used deuterium magnetic resonance to study dietary influences on lipid synthesis demonstrating that high fat ketogenic diets significantly slow de novo lipogenesis, a process by which excess carbohydrates are covered into fatty acids and stored as triacylglycerols.
Respiratory insufficiency is a leading cause of death due to drug overdose or spinal cord injuries. The diaphragm can be stimulated using temporal interference (TI) to restore ventilation with minimally invasive electrodes.
Understanding the organic composition of peat wetland soils can determine whether the carbon sources may be converted into carbon dioxide gas, work that could improve existing climate models and better predict the impact of increasing carbon dioxide to wetland ecosystems.
MRI scans taken after a stroke show brightness around the injury, the origins of which have been a long-standing and vexatious mystery for scientists. This work suggests these MRI signal changes result from fluid changes in glial cell volumes, results that could advance our ability to distinguish reversible and irreversible stroke events or provide a better understanding for other disorders such as Parkinson's, Alzheimer's, and mood or sleep disorders.
Using NMR, researchers determined a molecular model of a protein-polymer conjugate, providing new insights into how polymers can be used to make protein drugs more robust.
Special protein-coupled receptors play a role in nearly all physiological responses and are targets for more than 1/3 of all FDA-approved drugs. State-of-the art instrumentation at the MagLab allowed researchers to explore the effects of different lipid compositions on receptor activation, hinting that hereditary or dietary factors may influence the effectiveness of drugs.
The causes of migraines are not well understood, with treatment limited to addressing pain rather than its origin. Research conducted with hydrogen MRI is attempting to identify the "migraine generator."
With unprecedented sensitivity and resolution from state-of-the-art magnets, scientists have identified for the first time the cell wall structure of one of the most prevalent and deadly fungi.
With advanced techniques and world-record magnetic fields, researchers have detected new MRI signals from brain tumors.
Very high magnetic fields now enable researchers to understand what surrounds calcium atoms in materials.
This finding demonstrates a path forward to dramatically enhance sensitivity for molecule concentration measurement by magnetic resonance using Overhauser DNP.
Magnetic resonance (MR) signals of sodium and potassium nuclei during ion binding are attracting increased attention as a potential biomarker of in vivo cell energy metabolism. This new analytical tool helps describe and visualize the results of MR experiments in the presence of in vivo ion binding.
Metal-organic frameworks (MOFs) are porous materials with high surface areas that can host a variety of different guest molecules, leading to applications in catalysis, drug delivery, chemical separation, fuel cells, and data storage. In order to design better MOFs, knowledge of their molecular-level structures is crucial. At the MagLab, the highest-field NMR spectrometer in the world was used to probe the complex structures of MOFs both "as built" and as they exist when other "guest" molecules are inserted inside the framework.
Measurements performed at the National High Magnetic Field Laboratory provide unique insight into molecular structure of next-generation catalysts for the production of the widely used industrial chemical, propene.
A new method to study how the nuclei of atoms “communicate” with one another in the presence of unpaired electron spins has been developed at the MagLab. Known as hyperpolarization resurgence (HypRes), this method benefits and expands the application of a revolutionary technique known as dynamic nuclear polarization (DNP), which provides enormous signal enhancements in nuclear magnetic resonance (NMR) experiments.
Scientists have used high-field nuclear magnetic resonance (NMR) to reveal how fungal pathogens use carbohydrates and proteins to build their cell walls (the protective layers outside of the cell). These findings will guide the development of novel antifungal drugs that target the cell wall molecules to combat life-threatening diseases caused by invasive fungal infections.
A new 17O solid-state NMR technique, employed on the highest-field NMR spectrometer in the world (the 36 T Series Connected Hybrid), identifies water molecules in different layers of a model membrane for the first time.
Zeolite catalysts are critical to generating the molecules that provide the building blocks of society’s energy and materials needs. Discerning a clear atomic-level picture of the active sites remains challenging for most current technologies, but here we show that solid-state nuclear magnetic resonance (ssNMR) methods coupled with ultra-high magnetic field instruments, can and has provided extremely useful information for catalyst development.
Chemists are rarely able to use oxygen NMR to determine molecular structures, since 17O is an extremely challenging nucleus to observe. This work provides a mechanism for obtaining a complete set of 17O NMR parameters for a glucose molecule, paving the way for researchers to consider 17O NMR as a new spectroscopic tool.
Evolutionary biologists reused FAIR data generated at the MagLab's NMR facility to model an RNA-binding protein in mammals dating back 160 million years and to explore how evolution and natural selection have influenced the structure of the protein. Their work suggests new strategies for improving our understanding of this protein, which could lead to improved therapies for neurodegenerative diseases like ALS.
MagLab scientists and engineers have developed a special coating on Bi-2212 superconducting wire for electrical insulation in superconducting magnets that will enable the wire to be used in ultra-high field nuclear magnetic resonance magnets.
A new "hot bronze" thin film growth recipe was developed to produce high quality superconducting Niobium-Tin (Nb3Sn) films that are easier to fabricate and that outperform existing technologies.
Combining tremendous strength with a high-quality field, the MagLab’s newest instrument promises big advances in interdisciplinary research.
Research sheds new light on the formation of harmful structures that can lead to neurodegenerative diseases.
Finding could make pricey, massive scanners a thing of the past.
Findings that “go against the textbooks” may improve biofuel production.
Findings clarify the role of sodium increase early in migraines and point to the region where symptoms may start.
Lab veteran Tim Cross has been named 2019-2020 Lawton Distinguished Professor by his peers.
The compact coil could lead to a new generation of magnets for biomedical research, nuclear fusion reactors and many applications in between.
Researchers at the National MagLab will study the role sodium plays in this painful disease and test treatments that could offer relief.
As head of nuclear magnetic resonance at the MagLab's Tallahassee headquarters, Rob Schurko hopes to expand capabilities and build new magnets.
Molecular architecture of fungal cell walls and the structural responses to stresses revealed in new paper.
With the most powerful MRI machine in the world, you can do cutting-edge studies on neurodegenerative diseases, cancer, tobacco use, muscles and more.
Sodium MRI techniques point to better cancer treatments.
What are the ten coolest (and most surprising) things about the world's strongest MRI magnet?
Two MagLab teams tried marrying vastly different technologies to build a new type of magnet: the Series Connected Hybrid. Decades later, has the oddball pairing panned out?
Researcher digs below the coronavirus's membrane in search of another layer of infection-causing proteins.
For membrane protein expert Tim Cross, solving the structure of a misunderstood protein put retirement on hold.
The virus that causes COVID-19 has thousands of potential drug targets. A global team is on a hunt for the best candidates.
A team of experts believes stem cells could be a route to a fast, effective therapy.
What happens when a kid with ADHD sustains a concussion? Using high-field magnets, researchers are working to find out.
Using advanced MRI, a mechanical engineer tackles the question: "Why do you have these big fluid spaces in your head?"
It's freaking hard to examine proteins closely in their native habitat. With the help of very clever magnet instrumentation, University of Texas scientist Kendra Frederick is up for the challenge.
Andreas Neubauer took the extended stay option during his recent trip to the MagLab. After all, you can't rush art — especially when it's mixed with science.
Why are scientists putting a mouse in the MagLab's magnets? A scientist is developing an MRI technique to detect kidney disease that lights up the organs' metabolism.
With the help of the world's strongest MRI machine, a scientist uses a novel technique to pinpoint ground zero for a migraine.
Looking for clues on climate change, a scientist digs up the dirt on peat from around the world.
Each day at work, Long, tackles the twin duties of providing administrative leadership for a growing program, and her own scientific research.
In the hands of Peter Gor'kov, scientific tools become works of fine art.
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- 600 MHz 89 mm MAS DNP System