Tag: Mass spectrometry
Mass spectrometers are instruments that give scientists information on the composition of a material. Mass spectrometers can pick apart complex substances and analyze their atoms and molecules by observing how they react to magnetic fields.
Mass spectrometers are instruments that give scientists insight into the composition of complex materials. These spectrometers can analyze materials and identify atoms and molecules by examining how they react to magnetic fields.
It's hard enough to weigh something as itty bitty as atoms or molecules. Factor in that they're careening by faster than Jeff Gordon on steroids, and you get an idea what scientists are up against. Using comet particles from NASA's Stardust mission as an example, this article explains how scientists measure atoms, and what kind of secrets they can uncover in the process.
It may look like a simple black blob, but an oil drop is in fact a phenomenally complex mix of immense (relatively speaking) molecules called hydrocarbons. Using a type of mass spectrometry called FT-ICR (in which the MagLab is a world leader), scientists can analyze oil and other macromolecules with amazing precision, uncovering important secrets in the process.
Protein oxidative damage is a common occurrence in a number of diseases, including cancer, neurodegenerative, and cardiovascular disease. Yet, little is known about its contribution to these illnesses. We developed a new technique, utilizing an infrared laser in combination with a mass spectrometer, to selectively identify sites of oxidation in complex protein mixtures. This sensitive and rapid platform may outperform current techniques and thus shed light on the involvement of oxidative damage in each of these diseases.
Molecular fossils of chlorophyll (called porphyrins) more than 1.1 billion years old find suggest that photosynthesis began 600 million years earlier than previously established.
Researchers have discovered a new method to create encapsulated carbon nanomaterials that contain fluorine. Known as fullerenes, these nanocages are promising candidates for clean energy applications.
Scientists will be able to apply the technique to characterize similar molecules, helping develop vaccines and drugs to treat bacterial infection.
Precise determination of hemoglobin sequence and subunit quantitation from human blood for diagnosis of hemoglobin-based diseases.
A new method to characterize crude oil corrosion shows that corrosion in acidic crude oils depends on the specific structures of the acid molecules, information that can help improve oil valuation and refining.
Combining spatial imaging technology with ultrahigh performance FT-ICR mass spectrometry provides users with the unique ability to create tissue images of identified biomolecules. This technology will be applied to understand human health and disease.
Road asphalt is made from aggregate (rocks) mixed with a "binder” from the residue remaining after extraction of gasoline and oils from petroleum crude oil. Until recently, this binder was thought to be chemically unreactive. Maglab scientists subjected a thin film of asphalt binder to simulated sunlight in the laboratory and used ultrahigh resolution mass spectrometry to reveal thousands of new, water-soluble chemicals that could be released into the environment by rainfall.
Researchers share new insights on the role of seasonality in dissolved organic matter (DOM) composition in large Arctic rivers. Researchers share new insights on the role of seasonality in dissolved organic matter (DOM) composition in large Arctic rivers.
A new Blood Proteoform Atlas maps 30,000 unique proteoforms as they appear in 21 different cell types found in human blood. The MagLab's 21 tesla FT-ICR mass spectrometer contributed nearly a third of the atlas' proteoforms.
Using the world's most powerful mass spectrometer, scientists have developed a new method to profile complex PFAS mixtures at the molecular level, facilitating future PFAS characterization in support of environmental and human health studies.
New technique could lead to precise, personalized cancer diagnosis and monitoring.
New research shows that high concentrations of polycyclic aromatic hydrocarbons (PAHs) found in coal tar pavement sealants are oxidized into toxic, water-soluble compounds by sunlight and subsequently washed into the environment by rainwater, polluting natural water systems, negatively impacting marine ecosystems and public health.
Researchers used the MagLab to produce the first clarified map of KRAS proteins in colon cancer tumors. Twenty-eight additional forms of the KRAS protein were discovered, including a new form of the protein (called clipped-KRAS) that does not bind to the cell membrane, instead serving as a kind of on-off switch to regulate cell growth. These findings may help yield future cancer treatments.
Reuse of the MagLab's Ion Cyclotron Resonance facility data improved understanding of protein fragmentation and aided the design and release of new algorithms and software tools. This is representative of a new type of MagLab user: A Data User – who accesses MagLab data from public data repositories to advance independent research goals.
State-of-the-art ion cyclotron resonance magnet system offers researchers significantly more power and accuracy than ever before.
Martha Chacón-Patiño to jump-start collaboration that could advance both the treatment of cancer and the study of petroleum.
Using tools at the MagLab, scientists pinpoint pigments that are the oldest on record.
Vincent Salters joins the elite ranks of American Geophysical Union fellows.
In a uranium-based compound once dismissed as boring, scientists watched superconductivity arise, perish, then return to life under the influence of high magnetic fields.
Enabled by a world-record instrument, the images convey vast amounts of data that could be useful in health and pharmaceutical research.
MagLab researchers show that exposure to sun and water causes thousands of chemicals to leach from roads into the environment.
Learn how the MagLab's high-field magnets are helping uncover the secrets of "forever chemicals."
The MagLab and the Bruker Corporation have installed the world’s first 21 tesla magnet for Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometry.
At research conducted at the MagLab, a young geochemist uncovers the surprisingly violent origins of a meteorite.
Thanks to the MagLab’s expertise and unique instruments, a geochemist finds a treasure trove of oil-spill data buried beneath the sea.
Studying dissolved organic matter helps us better understand our diverse and changing planet.
Members of a sprawling science team piece together the puzzle of biochar, a promising tool in the fight against global warming.
Used to perform complex chemical analysis, this magnet offers researchers the world's highest field for ion cyclotron resonance mass spectrometry.
A young chemist studying fracking fluid talks about what it's like when science hits close to home.
Paleobiogeochemist (no, that's not a typo) Nur Gueneli put some ancient dirt into our magnets to learn more about the Earth's earliest inhabitants.
ICR technology helps identify new kinds of hemoglobin abnormalities.
Chemist Amy McKenna describes her path to science and to the MagLab
MagLab scientist Yang Wang joins an expedition to unearth the oldest woolly rhino fossils ever found.
With determination, confidence and a top-notch team, this MagLab chemist exposed the complex secrets of crude oil, busting open a vast, new field.
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