Nuclear Magnetic Resonance and Magnetic Resonance Imaging / Spectroscopy

900 MHz 105 mm Bore NMR Magnet

Users Michael Harrington (Huntington Medical Research Institute). left, and Eduard Chekmenev (Vanderbilt University), right , work with staff scientist Victor Schepkin on the 900.

900 MHz 105 mm Bore NMR Magnet

4.7 Tesla 33 cm MRI/S System

Located at AMRIS at our University of Florida campus in Gainesville.

4.7 Tesla 33 cm MRI/S System

Technology Development

We are world leaders in designing and building probes and other NMR-MRI/S instrumentation.

An NMR probe.

High-resolution Imaging

Viewing images obtained with the 3 tesla 90 cm MRI scanner at the Advanced Magnetic Resonance Imaging and Spectroscopy Facility at the University of Florida in Gainesville.

MRi images

NMR - MRI/S techniques and instruments are available at two different MagLab facilities in Florida: The NMR-MRI/S Facility at MagLab headquarters near Florida State University in Tallahassee and the Advanced Magnetic Resonance Imaging and Spectroscopy Facility (AMRIS) housed within the McKnight Brain Institute at the University of Florida in Gainesville.

Working in tandem, these facilities combine unique magnets, equipment and expert scientific support with advanced capabilities for technique and instrumentation development. About 20 spectrometers and scanners are available for use with an array of solid state, solution state, MRI/S (animal and human), MR microscopy and diffusion capabilities and techniques.

map of Tallahassee and Gainesville, Florida

 

Our unique instruments include the 900 MHz 105 mm bore magnet — the world's strongest MRI machine — at our FSU location and a 600 MHz, triple-resonance probe at AMRIS that appears to deliver the highest mass sensitivity of any probe at any frequency, enabling natural-products research when sample size is small or limited.

Magnet time is free and allocated on the basis of scientific peer review; we accept proposals throughout the year. While many users conduct their experiments in person, an increasing number also work remotely with the help of our dedicated staff.

HOW TO APPLY

Our magnets are open to all scientists — for free — via a competitive process; we accept proposals throughout the year.

  1. Prepare documentation
    A proposal and prior results report are required.
  2. Create a user profile
    Returning users simply need to log in.
  3. Submit a request online
    Upload files and provide details about the proposed experiment.
  4. Report your results
    Submit a 1-page report and info on publications resulting from your experiment.

Read the User Proposal Policy for complete guidelines or contact NMR-MRI/S Facility Director Tim Cross or AMRIS Facility Director Joanna Long.

AMRIS

 

Latest Science Highlight



Featured Publications

13C NMR Metabolomics: Applications at Natural Abundance

C.S. Clendinen, et al., Analytical Chemistry, 86 (18), 9242-9250 (2014) See Science Highlight or Read online …


Single-File Nanochannel Persistence Lengths from NMR

M. Dvoyashkin, et al., Anal. Chem., 286 (4), 2200-2204 (2014) Read online …


Gene transfer of arginine kinase to skeletal muscle using adeno-associated virus

S.C. Forbes, et al., Gene Therapy, 21 (4), 387-392 (2014) Read online …


On Random Walks and Entropy in Diffusion-Weighted Magnetic Resonance Imaging Studies of Neural Tissue

C. Ingo, et al., Magnet. Reson. Med., 71 (2), 617-627 (2014) Read online …


Absolute Magnetic Susceptibility of Rat Brain Tissue

M.K. Peprah, et al., Magnet. Reson. Med., 72, 876-879 (2014) Read online …

See more AMRIS publications

NMR-MRI/S Facility

 

Latest Science Highlight


  • An approach for dynamic nuclear polarization of membrane proteins
    12 May 2015
    An approach for dynamic nuclear polarization of membrane proteins

    Dynamic nuclear polarization (DNP) coupled with solid state NMR can provide orders of magnitude enhancement to normally weak NMR signals, thereby enabling the study of inherently dilute proteins such as membrane proteins. Here we demonstrate a new approach to obtain DNP signal enhancements of membrane proteins by utilizing spin labeled lipids as the polarization agents. This strategy results in more than 2x in signal enhancements of a membrane protein when compared to standard DNP sample preparation techniques.

    Read more...

Featured Publications

Sodium 3D COncentration MApping (COMA 3D) using 23Na and proton MRI

M.L. Truong, et al., Journal of Magnetic Resonance, 247 (2014) Go to Developed Software or Read online …


Structure of CrgA, a cell division structural and regulatory protein from Mycobacterium tuberculosis, in lipid bilayers

N. Das, et al., Proc Natl Acad Sci USA, vol. 112 no. 2. (2014) See Science Highlight or Read online …


Multimodal nanoprobes to target cerebrovascular amyloid in Alzheimer’s disease brain

K.M. Jaruszewski, et al., Biomaterials, 35(6):1967-76 (2014) Read online …


Binding of MgtR, a Salmonella Transmembrane Regulatory Peptide, to MgtC, a Mycobacterium tuberculosis Virulence Factor: A Structural Study

F.L. Jean-Francois, et al., J. Mol. Biol., 426:436-446. PMID: 24140750. (2014) Read online …

See more NMR-MRI/S Facility publications


For more information contact NMR-MRI/S Facility Director Tim Cross or AMRIS Facility Director Joanna Long

Last modified on 18 March 2015