Shinho Cho

Postdoctoral Fellow, Radiology/Neurosurgery, Mayo Clinic, Rochester, MN, 2017
Ph.D. in Cognitive and Brain Science, University of Minnesota, 2015
M.S. in Cognitive Science, Yonsei University, Korea, 2008
B.S. in Computer Science, Yonsei University, Korea, 2006

Dr. Shinho Cho serves as the Associate Director for the MRI User Program (21.1T/900 MHz system) in the NMR/MRI(S) division. With over 15 years of expertise, his research primarily focuses on:

• Ultra-high-field MRI (16.4T and 21.1T) applied to neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.
• Functional MRI (a.k.a. BOLD imaging) and multimodal imaging (2-photon microscopy) to investigate hemodynamic and vasodynamic mechanisms underlying brain activation.
• Neuromodulation techniques, including Deep Brain Stimulation (DBS), sensory stimulation (visual/olfactory), chemogenetics (DREADDs), and optogenetics combined with simultaneous fMRI for preclinical research in motor and reward circuitry modulation.
• Development of advanced MR contrast agents for functional neuroimaging, blood volume measurement, and neurotransmitter detection under ultra-high-field MRI.
• Functional and structural connectivity techniques applied to the early detection, diagnosis, and prognosis of neurological, neurodegenerative, and psychiatric disorders.

ONGOING PROJECTS (2023-2025):

• Investigating the neurotoxicity and neuroinflammation caused by beta-amyloid oligomer injections in rodent models using longitudinal (f)MRI for early Alzheimer’s detection and cognitive/behavioral symptom monitoring.
• Analyzing the correlation and causal relationship between deep brain and brainstem connectivity with sleep patterns, wakefulness, and abnormalities leading to sleep disorders or consciousness disorders (e.g., coma).
• Characterizing the effects of genetic and cellular factors on alcohol addiction and its impact on reward networks using chemogenetic MRI
• Developing low-toxicity manganese-based MR contrast agents (MEMRI) for neurotoxicity measurement and modification.
• Exploring pulse-sequence-based novel contrast mechanisms in ultra-high-field MRI using spatiotemporal encoding sequences for preclinical imaging applications.

OPEN TO COLLABORATION IN:

• Preclinical/basic neuroscience animal MRI, and Pharmacological (f)MRI
• Novel MR-contrast agent development
• !!!HIGH NEEDS!!! Ultra-high-field MRI technical development (pulse sequence techniques, image reconstruction, and RF coil development)
• !!!HIGH NEEDS!!! Post-processing methods, such as denoising, mathematical modeling, and AI-based data analysis

*** INTERESTED COLLABORATORS MAY SEND A BRIEF RESEARCH DESCRIPTION TO DR. CHO (scho at magnet.fsu.edu)

Associate Director of MRI User Program, National High Magnetic Field Laboratory (2024 – Present)
Faculty (Research Faculty I), National High Magnetic Field Laboratory (2023 – Present)
Scientist, Center for Magnetic Resonance Research (CMRR), University of Minnesota Medical School (2017 – 2023)
Research Fellow (Postdoctoral), Department of Neurosurgery, Mayo Clinic, Rochester, MN (2015 – 2017)

Publications & Research Output
Peer-reviewed Journal Articles: 14 publications, Conference Proceedings: 10+ presentations

Selected Publications:

Shinho Cho, Arani Roy, Chao J. Liu, Djaudat Idiyatullin, Wei Zhu, Yi Zhang, Xiao-Hong Zhu, Phillip O’Herron, Austin Leikvoll, Wei Che, Prakash Kara, and Kâmil Uğurbil (2022). Cortical layer-specific differences in stimulus selectivity revealed with high-field fMRI and single-vessel resolution optical imaging of the primary visual cortex. NeuroImage, 118978.

Shinho Cho, Hoon Ki Min, Myung-Ho In, Hang Joon Jo (2020). Multivariate pattern classification on BOLD activation pattern induced by deep brain stimulation in motor, associative, and limbic brain networks. Scientific reports, 10(1), 1-12.

Shinho Cho, Jan Hachmann, Irena Balzekas, Myung-Ho In, Lindsey Andres‐Beck, Kendall Lee, Hoon-Ki Min, Hang Joon Jo (2019). Resting‐state functional connectivity modulates the BOLD activation induced by nucleus accumbens stimulation in the swine brain. Brain and behavior, 9(12), e01431.

Shinho Cho, Sheng He (2019). Size-invariant but location-specific object-viewpoint adaptation in the absence of awareness. Cognition, 192, 104035.

William S. Gibson, Shinho Cho, Osama Abulseoud, Krzysztof Gorny, Joel Felmlee, Kirk Welker, Bryan Klassen, Hoon-ki Min, & Kendall Lee (2016). The Impact of Mirth-Inducing Ventral Striatal Deep Brain Stimulation on Functional and Effective Connectivity. Cerebral Cortex, 1, 12.

William S. Gibson, Hang Joon Jo, Paola Testini, Shinho Cho, Joel P. Felmlee, Kirk M. Welker, Bryan T. Klassen, Hoon-Ki Min, Kendall H. Lee (2016) Functional Correlates of the Therapeutic and Adverse Effects Evoked by Thalamic Stimulation for Essential Tremor, Brain, 139(8), 2198-2210.

ACADEMIC AND PROFESSIONAL SERVICE
• Professional Societies:
Member, International Society for Magnetic Resonance in Medicine (ISMRM)
Member, Society for Neuroscience
Member, Vision Science Society
• Journal Review & Editorial Activities:
Reviewer for PLOS ONE (2013, 2020, 2021)
• Student Supervision & Mentoring:
Undergraduate Research Opportunity Program (2024) – Two undergraduate students
Mentored 5+ undergraduate students and 2 medical residents

CHO Research Group Website LINK HERE (Coming Soon)