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NMR Science Highlights

Schematic representation of the phosphonoglycans that decorate the slime proteins

December 15, 2023

A protein modification rarely found in terrestrial animals was discovered in the slime of the velvet worm. This slime, which is projected for prey cap…


17O is now added to the NMR toolkit, along with 1H, 13C and 15N, to characterize biomolecules like peptides, proteins, and enzymes.

September 11, 2023

Combining high magnetic fields, specialized probes, and measurement techniques, this work adds the crucial 17O nucleus into the study of biomolecules …


Dimer formation of α-D-glucose molecules in the crystal lattice of  D-glucose/NaCl (1:1) co-crystal.

April 24, 2023

Chemists are rarely able to use oxygen NMR to determine molecular structures, since 17O is an extremely challenging nucleus to observe. This work prov…


Left: A zeolite micropore and pair of active sites. Right: The signal-to-noise and spectral resolution in 17O NMR spectra is significantly enhanced at higher magnetic fields.

November 14, 2022

Zeolite catalysts are critical to generating the molecules that provide the building blocks of society’s energy and materials needs. Discerning a clea…


A schematic model for the hydrated phospholipid bilayer, which is a model of biological membranes.

August 15, 2022

A new 17O solid-state NMR technique, employed on the highest-field NMR spectrometer in the world (the 36 T Series Connected Hybrid), identifies water …


The NMR experiments revealed that formation of the liquid and hydrogel states of FUS is controlled by phosphorylation and stabilized by hydrogen bonding among a core region of 57 amino acids.

June 17, 2022

Evolutionary biologists reused FAIR data generated at the MagLab's NMR facility to model an RNA-binding protein in mammals dating back 160 million yea…


The protein tryptophan synthase showing the active site (red) with hydrogen atoms.

April 19, 2022

This new technique for mapping out atom placements in the active site of enzymes could unlock the potential for finding new therapeutics.


Structural model of fungal cell walls supported by extensive solid-state NMR data.

January 25, 2022

Scientists have used high-field nuclear magnetic resonance (NMR) to reveal how fungal pathogens use carbohydrates and proteins to build their cell wal…


The HypRes experiment, along with plots of 1H polarization for bulk (blue) and core (red) spins.

July 22, 2021

A new method to study how the nuclei of atoms “communicate” with one another in the presence of unpaired electron spins has been developed at the MagL…


Figure

April 28, 2021

Measurements performed at the National High Magnetic Field Laboratory provide unique insight into molecular structure of next-generation catalysts for…


The α-Mg3(HCOO)6 metal-organic framework that contains twelve unique oxygen sites.

October 16, 2020

Metal-organic frameworks (MOFs) are porous materials with high surface areas that can host a variety of different guest molecules, leading to applicat…


The computer based analytical tool is illustrated by visualization of the TQ MR signals inside the traditional TQ RF pulse sequence used to detect bound ions.

March 23, 2020

Magnetic resonance (MR) signals of sodium and potassium nuclei during ion binding are attracting increased attention as a potential biomarker of in vi…


A microwave beam (rainbow and solid blue arrow) is used to excite a free electron (purple), which in turn enhances (dashed blue arrows) magnetic resonance signals (black arrows) on near-by carbon atoms (yellow), thus allowing high sensitivity in combination with high-resolution.

December 12, 2019

This finding demonstrates a path forward to dramatically enhance sensitivity for molecule concentration measurement by magnetic resonance using Overha…


Magnetic Resonance studies of calcium to measure the local environments around the calcium atoms.

July 29, 2019

Very high magnetic fields now enable researchers to understand what surrounds calcium atoms in materials.


Quantitative chemical exchange saturation transfer (CEST) signals obtained on a rat brain with a tumor (red circled region).

March 20, 2019

With advanced techniques and world-record magnetic fields, researchers have detected new MRI signals from brain tumors.


Left: Two-dimensional 13C-13C spectra. Right: Representative structure of glycans

January 04, 2019

With unprecedented sensitivity and resolution from state-of-the-art magnets, scientists have identified for the first time the cell wall structure of …


Using MagLab-developed NMR pulse sequences, volumes in the rat cortex (pink boxes) are selected to acquire relaxation-enhanced 1H NMR spectra over 3 hours.

July 10, 2018

The causes of migraines are not well understood, with treatment limited to addressing pain rather than its origin. Research conducted with hydrogen MR…