Our group, composed of several scientists from different backgrounds (physics, chemistry and engineering), reflecting a joint effort from the EMR and NMR divisions, has developed a liquid Overhauser DNP instrument at 14.1 T (NMR 1H at 600 MHz) to dramatically increase the sensitivity of liquid NMR spectroscopy. This instrument is currently in its final development stage to measure small molecules applied to areas of research such as natural products, metabolomics.
This system shares a gyrotron, the 395 GHz microwave source, with the MAS-DNP NMR user instrument. The NMR part of the instrument is performed using a Tecmag console (3 channels with a lock) in combination with an Oxford Instruments 51-mm bore 14.1-T magnet. Two liquid DNP probes are available, a 3-mm HCN and a 3-mm XH. Both probes are fitted with sweep coils to fine tune the magnetic field to match the resonant conditions of the radical used.
Scientific details can be found at:
The Overhauser DNP spectrometer is not part of the user program (yet). This instrument is currently in its final development stage to measure small molecules applied to areas of research such as natural products, metabolomics.
One gyrotron (395 GHz microwave source). Two 600 MHz DNP spectrometers: MAS-DNP user facility, liquid Overhauser DNP development instrument. The quasi-optical system allows the use of both DNP spectrometers simultaneously using a single gyrotron source.
Last modified on 28 December 2022