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MAS Dynamic Nuclear Polarization

DNP has been demonstrated to increase the sensitivity of NMR experiments by several orders of magnitude, which can lead to additional information about the systems being studied and drastically reduce experimental acquisition times.

In short, DNP uses microwave radiation to transfer the polarization from unpaired electron spins, present on stable radicals, to the nuclear spins of NMR active nuclei in molecules of interest. This increases the nuclear spins polarization leading to NMR spectra with very high signal to noise ratio. The time savings are tremendous and experiments that were impossible can now be carried out in matter of minutes to hours.

A solid-state MAS-DNP system operating at 14.1 T/395 GHz is available. This instrument shares a gyrotron, the 395 GHz microwave source, with the in-house custom-designed solution NMR instrument.


Available Spectrometers

The following spectrometer are available for this technique:

  • Bruker 3.2 mm HXY low-temperature (100 K) MAS-DNP probe
  • Custom made 3.2 mm HXY low-temperature (100 K) MAS-DNP probe
  • Custom made 1.3 mm HXY low-temperature (100 K) MAS-DNP probe (upcoming)

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MAS-DNP setup at the MagLab

MAS-DNP setup

One gyrotron (395 GHz microwave source). Two 600 MHz DNP spectrometers: MAS-DNP user facility, liquid Overhauser DNP development instrument. The quasi-optical system allows the use of both DNP spectrometers simultaneously using a single gyrotron source.

Related Publications

Mentink-Vigier, F.; Eddy, S.; Gullion, T. MAS-DNP Enables NMR Studies of Insect Wings. Solid State Nucl. Magn. Reson. 2022, 101838.

Kirui, A.; Zhao, W.; Deligey, F.; Yang, H.; Kang, X.; Mentink-Vigier, F.; Wang, T. Carbohydrate-Aromatic Interface and Molecular Architecture of Lignocellulose. Nat. Commun. 2022, 13 (1), 538.

Holmes, J. B.; Liu, V.; Caulkins, B. G.; Hilario, E.; Ghosh, R. K.; Drago, V. N.; Young, R. P.; Romero, J. A.; Gill, A. D.; Bogie, P. M.; Paulino, J.; Wang, X.; Riviere, G.; Bosken, Y. K.; Struppe, J.; Hassan, A.; Guidoulianov, J.; Perrone, B.; Mentink-Vigier, F.; Chang, C. A.; Long, J. R.; Hooley, R. J.; Mueser, T. C.; Dunn, M. F.; Mueller, L. J. Imaging Active Site Chemistry and Protonation States: NMR Crystallography of the Tryptophan Synthase α-Aminoacrylate Intermediate. Proc. Natl. Acad. Sci. 2022, 119 (2), e2109235119.

Kang, X.; Kirui, A.; Muszyński, A.; Widanage, M. C. D.; Chen, A.; Azadi, P.; Wang, P.; Mentink-Vigier, F.; Wang, T. Molecular Architecture of Fungal Cell Walls Revealed by Solid-State NMR. Nat. Commun. 2018, 9 (1), 2747.

Lilly Thankamony, A. S.; Wittmann, J. J.; Kaushik, M.; Corzilius, B. Dynamic Nuclear Polarization for Sensitivity Enhancement in Modern Solid-State NMR. Prog. Nucl. Magn. Reson. Spectrosc. 2017, 102–103, 120–195.

Rankin, A. G. M.; Trébosc, J.; Pourpoint, F.; Amoureux, J. P.; Lafon, O. Recent Developments in MAS DNP-NMR of Materials. Solid State Nucl. Magn. Reson. 2019, 101 (May), 116–143.


Last modified on 28 December 2022

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