Liquid Overhauser Dynamic Nuclear Polarization

Our group, composed of several scientists from different backgrounds (physics, chemistry and engineering), reflecting a joint effort from the EMR and NMR divisions, has developed a liquid Overhauser DNP instrument at 14.1 T (NMR ¹H at 600 MHz) to dramatically increase the sensitivity of liquid NMR spectroscopy. This instrument is currently in its final development stage to measure small molecules applied to areas of research such as natural products, metabolomics.

This system shares a gyrotron, the 395 GHz microwave source, with the MAS-DNP NMR user instrument. The NMR part of the instrument is performed using a Tecmag console (3 channels with a lock) in combination with an Oxford Instruments 51-mm bore 14.1-T magnet. Two liquid DNP probes are available, a 3-mm HCN and a 3-mm XH. Both probes are fitted with sweep coils to fine tune the magnetic field to match the resonant conditions of the radical used.

Scientific details can be found at:

Thierry Dubroca, et al., A quasi-optical and corrugated waveguide microwave transmission system for simultaneous dynamic nuclear polarization NMR on two separate 14.1T spectrometers. Journal of Magnetic Resonance, Volume 289, April 2018, Pages 35-44. https://doi.org/10.1016/j.jmr.2018.01.015
Thierry Dubroca, et al., Large volume liquid state scalar Overhauser dynamic nuclear polarization at high magnetic field. Phys. Chem. Chem. Phys., 2019, 21, 21200-21204. DOI:10.1039/C9CP02997D
Murari Soundararajan, et al., Proton-detected solution-state NMR at 14.1T based on scalar-driven ¹³C Overhauser dynamic nuclear polarization. Journal of Magnetic Resonance ,Volume 343, October 2022, 107304. https://doi.org/10.1016/j.jmr.2022.107304

Details

Available Spectrometers

The Overhauser DNP spectrometer is not part of the user program (yet). This instrument is currently in its final development stage to measure small molecules applied to areas of research such as natural products, metabolomics.

Heterodyne Quasi-Optical Spectrometer
Transmission Spectrometer - Future
W-Band HiPER Spectrometer
XQ-Band Bruker Pulsed Spectrometer - Future
600 MHz Liquid Overhauser DNP

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MAS-DNP setup at the MagLab

MAS-DNP setup

One gyrotron (395 GHz microwave source). Two 600 MHz DNP spectrometers: MAS-DNP user facility, liquid Overhauser DNP development instrument. The quasi-optical system allows the use of both DNP spectrometers simultaneously using a single gyrotron source.

Contacts

Last modified on 22 August 2023

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