14 March 2015

First Structure of a Protein in the M. tuberculosis Cell Division Apparatus

CrgA, a key Mycobacterium tuberculosis cell division protein that recruits five other proteins to the cell division apparatus has been structurally characterized using oriented sample and magic angle spinning solid state NMR. The protein has two transmembrane helices and an intrinsically disordered N-terminus. Binding sites have been identified for it's binding partners. Evaluating these binding sites may lead to effective drugs for either promoting and inhibiting cell division, both of which are of prime interest for the treatment of tuberculosis.

For more information contact Tim Cross.

Details

  • Research Area: Biochemistry, Biology, Chemistry, Magnet Resonance Technique Development
  • Research Initiatives: Life
  • Facility / Program: NMR/MRI
  • Year: 2015
Last modified on 18 March 2015