NMR-MRI/S Science Highlights
Evolutionary biologists reused FAIR data generated at the MagLab's NMR facility to model an RNA-binding protein in mammals dating back 160 million years and to explore how evolution and natural selection have influenced the structure of the protein. Their work suggests new strategies for improving our understanding of this protein, which could lead to improved therapies for neurodegenerative diseases like ALS.
This new technique for mapping out atom placements in the active site of enzymes could unlock the potential for finding new therapeutics.
Scientists have used high-field nuclear magnetic resonance (NMR) to reveal how fungal pathogens use carbohydrates and proteins to build their cell walls (the protective layers outside of the cell). These findings will guide the development of novel antifungal drugs that target the cell wall molecules to combat life-threatening diseases caused by invasive fungal infections.
A new method to study how the nuclei of atoms “communicate” with one another in the presence of unpaired electron spins has been developed at the MagLab. Known as hyperpolarization resurgence (HypRes), this method benefits and expands the application of a revolutionary technique known as dynamic nuclear polarization (DNP), which provides enormous signal enhancements in nuclear magnetic resonance (NMR) experiments.
Measurements performed at the National High Magnetic Field Laboratory provide unique insight into molecular structure of next-generation catalysts for the production of the widely used industrial chemical, propene.
Metal-organic frameworks (MOFs) are porous materials with high surface areas that can host a variety of different guest molecules, leading to applications in catalysis, drug delivery, chemical separation, fuel cells, and data storage. In order to design better MOFs, knowledge of their molecular-level structures is crucial. At the MagLab, the highest-field NMR spectrometer in the world was used to probe the complex structures of MOFs both "as built" and as they exist when other "guest" molecules are inserted inside the framework.
Magnetic resonance (MR) signals of sodium and potassium nuclei during ion binding are attracting increased attention as a potential biomarker of in vivo cell energy metabolism. This new analytical tool helps describe and visualize the results of MR experiments in the presence of in vivo ion binding.
This finding demonstrates a path forward to dramatically enhance sensitivity for molecule concentration measurement by magnetic resonance using Overhauser DNP.
Very high magnetic fields now enable researchers to understand what surrounds calcium atoms in materials.
With advanced techniques and world-record magnetic fields, researchers have detected new MRI signals from brain tumors.
With unprecedented sensitivity and resolution from state-of-the-art magnets, scientists have identified for the first time the cell wall structure of one of the most prevalent and deadly fungi.
The causes of migraines are not well understood, with treatment limited to addressing pain rather than its origin. Research conducted with hydrogen MRI is attempting to identify the "migraine generator."
Scientists can now observe lithium moving through an electrolyte in real time.
High-resolution brain imaging provides evidence of depression, anxiety in diseased mice
Scientists using an MRI-friendly oxygen isotope have demonstrated a promising and safe method for identifying cancerous tumors.
Using an advanced technique, scientists discover that one of the most common substances in our everyday lives — glass — is more complex than we thought.
Scientists gain new insights into how protective shells form around retrovirus genomes, advancing the search for drugs that will combat them.
Inspired by the SIM card technology used in modern cell phones, MagLab engineers designed and built a versatile magnet probe that makes it easier and more efficient for scientists to see the structure of molecules.
Ten years ago the 900 Ultra-Wide Bore magnet became available to an international user community for Nuclear Magnetic Resonance spectroscopy and Magnetic Resonance Imaging at the National High Magnetic Field Lab. Since then 69 publications have been published from this instrument spanning many disciplines and the number of publications per year continues to increase with 26 in just the past 18 months demonstrating that state of the art data continues to be collected on this superb magnet.
Dynamic nuclear polarization (DNP) coupled with solid state NMR can provide orders of magnitude enhancement to normally weak NMR signals, thereby enabling the study of inherently dilute proteins such as membrane proteins. Here we demonstrate a new approach to obtain DNP signal enhancements of membrane proteins by utilizing spin labeled lipids as the polarization agents. This strategy results in more than 2x in signal enhancements of a membrane protein when compared to standard DNP sample preparation techniques.