AMRIS Science Highlights

27 March 2017

"Bath salt" drugs disrupt brain activity

Using functional magnetic resonance imaging, researchers observe how cocaine-like drug disrupts neural activity in rats.

27 September 2016

Compound found in worms opens door to discovery of countless more

Scientists have discovered and characterized an unusual, complex natural product produced in worms, a finding that suggests a whole body of discoveries awaits.

16 February 2016

Determining the structure of “death acids” in plants

Scientists analyzing maize affected by southern leaf blight determine the molecular structures of so-called “death acids.”

17 September 2015

Motion of Gas Molecules Through Nanotubes

When molecules are forced to pass through narrow holes in membranes, they must move one-by-one in single file. When this “No Passing!” rule is in effect, researchers have recently made the surprising discovery that mixing two gases can lead to faster motion of some of the molecules through the narrow holes.

13 May 2015

Magnetic Resonance Imaging of an intact fruit fly brain at 10 micron resolution

In this paper, we obtained the first brain map of a complete fruit fly head at 10 micron isotropic resolution, the highest ever reported by MR for a complete head. Using two complementary imaging sequences revealed the superior power of DWI to dissect the brain architecture at close to cellular resolution.

14 March 2015

13C NMR Metabolomics: Applications at Natural Abundance

13C NMR when used in metabolomics 1. Provides better peak list for database matching and spectral annotation, 2. Provides better group separation and loadings annotation when using multivariate statistical analysis, and 3. Prevents possible misidentification of metabolites.

17 September 2014

Imaging Gene Transfer and Muscle Metabolism

AMRIS 11.1 and 17.6T Magnets and probes were used to directly image gene expression in live mouse muscles with in vivo 31P NMR techniques.

15 May 2014

Anomalous Translational Diffusion in Neural Tissue

A new non-Brownian model of anomalous translational diffusion in nervous tissue is introduced and applied to the brain. This model provides new fractional order parameters of diffusion, entropy, waiting time and jump length that represent unique markers of morphology in neural tissue.

15 January 2014

Dissolution DNP Polarizer for In Vivo 13C MRI

The MagLab’s AMRIS facility has recently implemented dissolution DNP technology. The system utilizes a 5 T magnet in which samples are cooled to 14,000 gain in SNR on dissolution and injection into our 4.7T MRI/S scanner.

15 September 2013

Observation of Single-File Diffusion in Dipeptide Nanotubes

Researchers using pulsed field gradient NMR at the AMRIS facility found clear evidence for molecular single file diffusion of xenon gas confined inside model nanotube systems.

15 May 2013

1.5-mm High Temperature Superconducting NMR Probe Optimized for 13C

A new 1.5-mm high-temperature superconducting probe designed to detect carbon 13 will significantly enhance studies in natural products and metabolomics.

15 January 2013

Male and Female Mating Pheromones in Panagrellus redivivus

Nematodes are the most abundant animal on earth, and they live in virtually every ecological niche on earth. Parasitic species have a significant health and economic impact through the infection of crops, domestic animals, and humans. Therefore, we are working to unravel the chemical language used by nematodes, with the ultimate goals of better understanding the role of small molecules in regulating behavior and of developing new approaches to control nematode parasites.