4.7 Tesla 33 cm MRI/S System (Gainesville)

4.7 Tesla 33 cm MRI/S System ( 4.7 T/33 cm Agilent VNMRS) 4.7 Tesla 33 cm MRI/S System ( 4.7 T/33 cm Agilent VNMRS)

This instrument,4.7 T/33 cm Agilent VNMRS, is located at the MagLab's AMRIS Facility at the University of Florida in Gainesville.

We have recently implemented dissolution DNP technology in the AMRIS facility. Our system utilizes a 5 T magnet in which samples are cooled to <1.1 K. With microwave irradiation, we achieve 70% polarization of 13C nuclei in the polarizer; this translates to a >14,000 gain in SNR on dissolution and injection into our 4.7T MRI/S scanner. The custom design of the polarizer enables the use of dissolution DNP to study metabolic flux in vivo using a variety of NMR –active nuclei as well as the study of fundamental mechanisms of polarization enhancement. This polarizer is available to external users through the MagLab.

This active-shield horizontal magnet is equipped with an Agilent Direct-Drive 4-channel console running vnmrj 3.1a. This is a dedicated animal MRI system and a workhorse for animal model studies such as muscular dystrophy, drug additions, epilepsy, and tumor models, etc. Capabilities of dissolution DNP technology for in vivo animal models are available to external users through the MagLab.

Details

  • Specs

  • Coils

  • Techniques & Capabilities

  • Probes

  • Designation: Imaging
  • Location: Gainesville, LG123C
  • MHz: 200
  • Field: 4.7 tesla
  • Bore size: 33 cm
  • Homogeneity: 0.1ppm
  • Oxford 4.7 T 33 cm actively-shielded horizontal magnet
  • Agilent VNMRS console/VnmrJ3.1 with 4 1H /1 BB transmitter and 4 channel receivers
  • IECO GPA-400-750, 400A/750V peak 3-Axis MRI Gradient Amplifier
  • Open for users who would pay for magnet time: Yes

Gradient Coils

  • Oxford 330/225 – bore size 225mm, Gmax = 65 mT/m with 700 µs risetime
  • RRI BFG-200/115-S14 – bore size 115mm, Gmax = 670mT/m (@300A) with 120us risetime

RF Coils

  • 1H – 200MHz, solenoid linear 1.2cm
  • 1H – 200MHz, quadrature birdcage 3.3/6.2cm (Coil 301)
  • 1H – 200MHz, quadrature birdcage 5.0/8.8cm (Coil 302)
  • 1H – 200MHz, quadrature birdcage 9.5/14cm
  • 1H – 200MHz, quadrature birdcage TX-only, 8.8/11.6cm (Coil307)/ 3.0×3.5cm quadrature RX-only coil,
  • 1H – 200MHz, Varian quadrature birdcage 3.8/10.8cm
  • 1H – 200MHz, Varian quadrature birdcage 6.3/10.8cm
  • 1H – 200MHz, quadrature surface coil 2.0×3.0cm
  • 1H – 200MHz, quadrature surface coil 1.5×2.9cm
  • 1H – 200MHz, Four element surface array – each element 3.0cm x 3.0cm
  • 31P – 81MHz, 1.5cm diameter
  • 13C – 50MHz, 1.5cm diameter

MR Microscopy

MRI

  • 1H imaging probes
    • Quadrature birdcage 3.3/6.2cm (Coil 301)
    • Quadrature birdcage 5.0/8.8cm (Coil 302)
    • Quadrature birdcage 9.5/14cm
    • Quadrature birdcage TX-only, 8.8/11.6cm/ 3.0x3.5cm RX-only coil (Coil307)
    • Varian quadrature birdcage 3.8/10.8cm
    • Varian quadrature birdcage 6.3/10.8cm
    • Quadrature coil with integrated head fixture 3.8/11.5cm (for awaked rat brain imaging)
    • Quadrature coil 3.6/11.5cm (for awaked mouse brain imaging)
    • Solenoid linear coil 1.0cm ID (Coil 202)
    • Solenoid linear coil 1.2cm ID
    • Quadrature surface coil 2.0x3.0cm
    • Quadrature surface coil 1.5x2.9cm
    • Four element surface array - each element 3.0cm x 3.0cm
  • 31P spectroscopy - 1.5cm diameter surface coil
  • 13C spectroscopy - 1.5cm diameter surface coil

Images

Click on an image for larger view and details.

Staff Contact

For more information please contact Huadong Zeng.

Last modified on 8 September 2021