Infrared Multiphoton Dissociation

Infrared multiphoton dissociation (IRMPD) is often used in conjunction with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) to fragment gas-phase ions inside the ICR cell.

Infrared multiphoton dissociation (IRMPD) is often used in conjunction with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) to fragment gas-phase ions inside the ICR cell. A CO2 laser is aligned to send a beam of infrared photons through a window at the end of the vacuum chamber to the center of the ICR cell. The ions trapped at the center of the cell can absorb multiple photons if their vibration is resonant with the laser frequency. The ion’s absorption of photons results in the excitement of the ion to higher energy states, and ultimately dissociation if enough energy (in photons) is absorbed to break a bond within the ion. The amount of energy infused into the system is a function of laser power and irradiation time and is tunable.

tandem schemeSchematic of the MagLab’s 9.4 T FT-ICR mass spectrometer equipped with IRPMD capability

 

This technique can be used with the following instruments:

Related Publications

D. C. Podgorski, et al, Heavy Petroleum Composition. 5. Compositional and Structural Continuum of Petroleum Revealed, Energy Fuels 27(3), 1268-1276 (2013) Read online 


M. Schäfer, et al, Kinetic Determination of Potassium Affinities by IRMPD: Elucidation of Precursor Ion Structures, J. Phys. Chem. A. 113(27), 7779-7783 (2009) Read online 


M. Schäfer, et al, Structurally related non-covalent complexes examined by quadrupole ion trap (QIT) MS2 and infrared multiphoton dissociation Fourier transform ion cyclotron resonance mass spectrometry IRMPDFT-ICR MS: evidence for salt-bridge structures in the gas phase, International Journal of Mass Spectrometry 237(1), 33-45 (2004) Read online 


K. Håkansson, et al, Combined electron capture and infrared multiphoton dissociation for multistage MS/MS in a Fourier transform ion cyclotron resonance mass spectrometer, Analytical Chemistry 75(13), 3256-3262 (2003) Read online 


For more information please contact Amy McKenna, Manager, ICR User Program.

Last modified on 28 August 2015