Magnetic Resonance Imaging (MRI) of mouse models for Alzheimer’s disease can be used to determine brain response to plaque deposits and inflammation that ultimately disrupt emotion, learning, and memory. Quantification of the early changes with high resolution MRI could help monitor and predict disease progression, as well as potentially suggest new treatment methods.
Magnetic resonance (MR) signals of sodium and potassium nuclei during ion binding are attracting increased attention as a potential biomarker of in vivo cell energy metabolism. This new analytical tool helps describe and visualize the results of MR experiments in the presence of in vivo ion binding.
Little is known about the path of metabolic waste clearance from the brain. Here, high-field magnetic resonance images a possible pathway for metabolic waste removal from the brain and suggests that waste clearance may be one reason why we sleep.
This finding demonstrates a path forward to dramatically enhance sensitivity for molecule concentration measurement by magnetic resonance using Overhauser DNP.
Precise determination of hemoglobin sequence and subunit quantitation from human blood for diagnosis of hemoglobin-based diseases.
Researchers at the National MagLab will study the role sodium plays in this painful disease and test treatments that could offer relief.
Three variants of the coral species A cervicornis were found to have unique metabolic signatures that can be distinguished by NMR spectroscopy. Differing levels of the metabolite trimethylamine-N-oxide, an important compound that protects against nitrogen overload, can distinguish the three variants studied. Understanding how species vary metabolically, and how that translates to species survival in stressed environments, may help us to establish desirable traits that could help with restoration and other interventions.
With advanced techniques and world-record magnetic fields, researchers have detected new MRI signals from brain tumors.
Scientists will be able to apply the technique to characterize similar molecules, helping develop vaccines and drugs to treat bacterial infection.
With unprecedented sensitivity and resolution from state-of-the-art magnets, scientists have identified for the first time the cell wall structure of one of the most prevalent and deadly fungi.