17 June 2015

FT-ICR Mass Spectrometry Enables Peptide de novo Sequencing

We describe a method for de novo protein sequencing with high accuracy and multiple levels of confidence. Samples are digested separately by two proteases, Lys-C and Lys-N. The resulting complementary pairs of ions combine to improve confidence in the identification.

For more information contact Chris Hendrickson.


  • Research Area: Biochemistry, Biology
  • Research Initiatives: Life
  • Facility / Program: ICR
  • Year: 2015
Last modified on 17 June 2015