This facility is charged with developing and exploiting the unique capabilities of Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometry, and leads the world in instrument and technique development as well as novel applications of FT-ICR mass spectrometry.
The facility features directors for instrumentation, biological applications, environmental, petrochemical applications, and user services as well as a machinist, technician and numerous rotating postdocs who are available to collaborate and/or assist with projects.
The facility provides service operations for sample analysis that requires the ultrahigh resolution and high mass accuracy of FT-ICR. Research falls in the areas of biomolecular analysis, hydrogen-deuterium exchange and environmental and petrochemical analysis. The facility's four FT-ICR mass spectrometers feature high magnetic fields – including the world-record 21 tesla – and are compatible with multiple ionization and fragmentation techniques.
HOW TO APPLY
Our magnets are open to all scientists — for free — via a competitive process and we accept proposals throughout the year.
- Prepare documentation
A proposal and prior results report are required. - Create a user profile
Returning users simply need to log in. - Submit a request online
Upload files and provide details about the proposed experiment. - Report your results
By year’s end, submit a 1-page report and information on publications resulting from your experiment.
Please review the MagLab User Policies and Procedures before submitting your proposal and experimentor contact Facility Director Chris Hendrickson with questions. View User FAQs.
Latest Science Highlight
-
Targeted annotation of peptides by selective infrared multiphoton dissociation mass spectrometry
27 February 2018
Protein oxidative damage is a common occurrence in a number of diseases, including cancer, neurodegenerative, and cardiovascular disease. Yet, little is known about its contribution to these illnesses. We developed a new technique, utilizing an infrared laser in combination with a mass spectrometer, to selectively identify sites of oxidation in complex protein mixtures. This sensitive and rapid platform may outperform current techniques and thus shed light on the involvement of oxidative damage in each of these diseases.
Featured Publications
Targeted Annotation of Peptides by Selective Infrared Multiphoton Dissociation Mass Spectrometry
N.B. Borotto, et al., Analytical Chemistry (2017), 89, 8304-8310 See Science Highlight or Read online …
More accurate diagnosis for multiple myeloma
L. He, et al., Journal of the American Society for Mass Spectrometry (2017), 28 (5), 827-838 See Science Highlight or Read online …
Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry
L.C. Anderson, et al., Journal of Proteome Research (2017), 16 (2), 1087-1096 See Science Highlight or Read online …
For more information on the ICR Facility, contact one of the individuals listed below:
- Chris Hendrickson, ICR Facility Director
- Amy McKenna, Manager, ICR User Program
- Alan Marshall, Chief Scientist for Ion Cyclotron Resonance