Ion Cyclotron Resonance Facility (ICR)

World-record 21 tesla ICR magnet. World-record 21 tesla ICR magnet. Image: David Barfield

This facility is charged with developing and exploiting the unique capabilities of Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometry, and leads the world in instrument and technique development as well as novel applications of FT-ICR mass spectrometry.

The facility features directors for instrumentation, biological applications, environmental, petrochemical applications, and user services as well as a machinist, technician and numerous rotating postdocs who are available to collaborate and/or assist with projects.

map of Tallahassee, Florida

The facility provides service operations for sample analysis that requires the ultrahigh resolution and high mass accuracy of FT-ICR. Research falls in the areas of biomolecular analysis, hydrogen-deuterium exchange and environmental and petrochemical analysis. The facility's four FT-ICR mass spectrometers feature high magnetic fields – including the world-record 21 tesla – and are compatible with multiple ionization and fragmentation techniques.


Our magnets are open to all scientists — for free — via a competitive process and we accept proposals throughout the year.

  1. Prepare documentation
    A proposal and prior results report are required.
  2. Create a user profile
    Returning users simply need to log in.
  3. Submit a request online
    Upload files and provide details about the proposed experiment.
  4. Report your results
    By year’s end, submit a 1-page report and information on publications resulting from your experiment.

Read the User Proposal Policy for complete guidelines or contact Facility Director Chris Hendrickson with questions.

Latest Science Highlight

  • Protein modifications in human breast cancer
    14 October 2015
    Protein modifications in human breast cancer

    We have discovered biomarkers that make it possible to distinguish breast cancer cells from non-cancerous cells, based on identifying chemical modifications of histones, the molecules about which DNA strands are wound to keep them in the cell nucleus. The method uses a high-field magnet to spread out the signals from different parts of the histone, to locate the site(s) of chemical modifications.

See more ICR Science Highlights

Featured Publications

21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

C. L. Hendrickson, et al., J. Am. Soc. Mass Spectrom. (2015) Read online …

Paired single residue-transposed Lys-N and Lys-C digestions for label-free identification of N-terminal and C-terminal MS/MS peptide product ions: ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry for peptide de novo sequencing

N. C. Brownstein, et al., Rapid Communications in Mass Spectrometry, 29, 659-666 (2015) See Science Highlight or Read online …

Unprecedented Ultrahigh Resolution FT-ICR Mass Spectrometry and Parts-Per-Billion Mass Accuracy Enable Direct Characterization of Nickel and Vanadyl Porphyrins in Petroleum from Natural Seeps

A. McKenna, et al., Energy Fuels, 28 (4), pp 2454–2464 (2014) Read online …

See more ICR publications

For more information on the ICR Facility, contact one of the individuals listed below:

Last modified on 13 October 2015