Ion Cyclotron Resonance Facility (ICR)

World-record 21 tesla ICR magnet. World-record 21 tesla ICR magnet. Image: David Barfield

This facility is charged with developing and exploiting the unique capabilities of Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometry, and leads the world in instrument and technique development as well as novel applications of FT-ICR mass spectrometry.

The facility features directors for instrumentation, biological applications, environmental, petrochemical applications, and user services as well as a machinist, technician and numerous rotating postdocs who are available to collaborate and/or assist with projects.

map of Tallahassee, Florida

The facility provides service operations for sample analysis that requires the ultrahigh resolution and high mass accuracy of FT-ICR. Research falls in the areas of biomolecular analysis, hydrogen-deuterium exchange and environmental and petrochemical analysis. The facility's four FT-ICR mass spectrometers feature high magnetic fields – including the world-record 21 tesla – and are compatible with multiple ionization and fragmentation techniques.

HOW TO APPLY

Our magnets are open to all scientists — for free — via a competitive process and we accept proposals throughout the year.

  1. Prepare documentation
    A proposal and prior results report are required.
  2. Create a user profile
    Returning users simply need to log in.
  3. Submit a request online
    Upload files and provide details about the proposed experiment.
  4. Report your results
    By year’s end, submit a 1-page report and information on publications resulting from your experiment.

Read the User Proposal Policy for complete guidelines or contact Facility Director Chris Hendrickson with questions.

Latest Science Highlight


  • FT-ICR Mass Spectrometry Enables Peptide de novo Sequencing
    17 June 2015
    FT-ICR Mass Spectrometry  Enables Peptide de novo Sequencing

    We describe a method for de novo protein sequencing with high accuracy and multiple levels of confidence. Samples are digested separately by two proteases, Lys-C and Lys-N. The resulting complementary pairs of ions combine to improve confidence in the identification.

See more ICR Science Highlights

Featured Publications


21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

C. L. Hendrickson, et al., J. Am. Soc. Mass Spectrom. (2015) Read online …


Paired single residue-transposed Lys-N and Lys-C digestions for label-free identification of N-terminal and C-terminal MS/MS peptide product ions: ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry for peptide de novo sequencing

N. C. Brownstein, et al., Rapid Communications in Mass Spectrometry, 29, 659-666 (2015) See Science Highlight or Read online …


Unprecedented Ultrahigh Resolution FT-ICR Mass Spectrometry and Parts-Per-Billion Mass Accuracy Enable Direct Characterization of Nickel and Vanadyl Porphyrins in Petroleum from Natural Seeps

A. McKenna, et al., Energy Fuels, 28 (4), pp 2454–2464 (2014) Read online …

See more ICR publications


For more information on the ICR Facility, contact one of the individuals listed below:

Last modified on 3 September 2015