Search results (48)

Name Description
A new twist on DNA

Research sheds important light on the fundamental process of cell division.

Compound found in worms opens door to discovery of countless more

Scientists have discovered and characterized an unusual, complex natural product produced in worms, a finding that suggests a whole body of discoveries awaits.

Learning how protective shells form around retroviruses

Scientists gain new insights into how protective shells form around retrovirus genomes, advancing the search for drugs that will combat them.

Determining the structure of “death acids” in plants

Scientists analyzing maize affected by southern leaf blight determine the molecular structures of so-called “death acids.”

Cell phone technology makes for versatile NMR probes

Inspired by the SIM card technology used in modern cell phones, MagLab engineers designed and built a versatile magnet probe that makes it easier and more efficient for scientists to see the structure of molecules.

Protein modifications in human breast cancer

We have discovered biomarkers that make it possible to distinguish breast cancer cells from non-cancerous cells, based on identifying chemical modifications of histones, the molecules about which DNA strands are wound to keep them in the cell nucleus. The method uses a high-field magnet to spread out the signals from different parts of the histone, to locate the site(s) of chemical modifications.

A Decade of Science on the Ultra-Wide-Bore 900 MHz NMR Spectrometer

Ten years ago the 900 Ultra-Wide Bore magnet became available to an international user community for Nuclear Magnetic Resonance spectroscopy and Magnetic Resonance Imaging at the National High Magnetic Field Lab. Since then 69 publications have been published from this instrument spanning many disciplines and the number of publications per year continues to increase with 26 in just the past 18 months demonstrating that state of the art data continues to be collected on this superb magnet.

FT-ICR Mass Spectrometry Enables Peptide de novo Sequencing

We describe a method for de novo protein sequencing with high accuracy and multiple levels of confidence. Samples are digested separately by two proteases, Lys-C and Lys-N. The resulting complementary pairs of ions combine to improve confidence in the identification.

Magnetic Resonance Imaging of an intact fruit fly brain at 10 micron resolution

In this paper, we obtained the first brain map of a complete fruit fly head at 10 micron isotropic resolution, the highest ever reported by MR for a complete head. Using two complementary imaging sequences revealed the superior power of DWI to dissect the brain architecture at close to cellular resolution.

An approach for dynamic nuclear polarization of membrane proteins

Dynamic nuclear polarization (DNP) coupled with solid state NMR can provide orders of magnitude enhancement to normally weak NMR signals, thereby enabling the study of inherently dilute proteins such as membrane proteins. Here we demonstrate a new approach to obtain DNP signal enhancements of membrane proteins by utilizing spin labeled lipids as the polarization agents. This strategy results in more than 2x in signal enhancements of a membrane protein when compared to standard DNP sample preparation techniques.

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