Search results (65)
|Restoration of Breathing After Drug Overdose and Spinal Cord Injuries||
Respiratory insufficiency is a leading cause of death due to drug overdose or spinal cord injuries. The diaphragm can be stimulated using temporal interference (TI) to restore ventilation with minimally invasive electrodes.
|A New Method for Understanding Dynamic Nuclear Polarization||
A new method to study how the nuclei of atoms “communicate” with one another in the presence of unpaired electron spins has been developed at the MagLab. Known as hyperpolarization resurgence (HypRes), this method benefits and expands the application of a revolutionary technique known as dynamic nuclear polarization (DNP), which provides enormous signal enhancements in nuclear magnetic resonance (NMR) experiments.
|Makeup of Dissolved Organic Matter in Arctic Rivers||
Researchers share new insights on the role of seasonality in dissolved organic matter (DOM) composition in large Arctic rivers.
|Structure of Boron-Based Catalysts from 11B Solid-State NMR at 35.2T||
Measurements performed at the National High Magnetic Field Laboratory provide unique insight into molecular structure of next-generation catalysts for the production of the widely used industrial chemical, propene.
|Using Magnetic Resonance to Probe Lipid Synthesis in Response to Ketogenic Diet||
Non-alcoholic Fatty Liver Disease and its progression to more serious diseases will become the main cause for liver transplant in the next 5 years. Here, researchers used deuterium magnetic resonance to study dietary influences on lipid synthesis demonstrating that high fat ketogenic diets significantly slow de novo lipogenesis, a process by which excess carbohydrates are covered into fatty acids and stored as triacylglycerols.
|Prefractionation of Intact Proteins for Mass Spectrometry||
Analysis of intact proteins using mass spectrometry is a difficult task that can be simplified by prefractionation, a process in which protein mixtures are separated into simpler fractions based on size. Here, researchers developed a new method, PEPPI-MS, which uses low-cost materials and common lab equipment to make an important protein separation strategy widely available.
|Probing Metal Organic Frameworks with 17O NMR at 35.2 T||
Metal-organic frameworks (MOFs) are porous materials with high surface areas that can host a variety of different guest molecules, leading to applications in catalysis, drug delivery, chemical separation, fuel cells, and data storage. In order to design better MOFs, knowledge of their molecular-level structures is crucial. At the MagLab, the highest-field NMR spectrometer in the world was used to probe the complex structures of MOFs both "as built" and as they exist when other "guest" molecules are inserted inside the framework.
|Deuterium Magnetic Resonance Can Detect Cancer Metabolism||
Magnetic resonance of cancer cell metabolism is a novel technique to discern between cancerous and normal liver cells, providing a promising approach for cancer stage progression imaging without the harmful exposure of radiation.
|Ultrahigh Performance Molecular Imaging using the 21T ICR Magnet||
Combining spatial imaging technology with ultrahigh performance FT-ICR mass spectrometry provides users with the unique ability to create tissue images of identified biomolecules. This technology will be applied to understand human health and disease.
|MRI detects brain responses to Alzheimer's disease plaque deposits and inflammation||
Magnetic Resonance Imaging (MRI) of mouse models for Alzheimer’s disease can be used to determine brain response to plaque deposits and inflammation that ultimately disrupt emotion, learning, and memory. Quantification of the early changes with high resolution MRI could help monitor and predict disease progression, as well as potentially suggest new treatment methods.