Search results (74)
|Mystery of the Origin of MRI Signal in Stroke Solved||
MRI scans taken after a stroke show brightness around the injury, the origins of which have been a long-standing and vexatious mystery for scientists. This work suggests these MRI signal changes result from fluid changes in glial cell volumes, results that could advance our ability to distinguish reversible and irreversible stroke events or provide a better understanding for other disorders such as Parkinson's, Alzheimer's, and mood or sleep disorders.
|Finding Water Molecules with Important Biological Activity||
A new 17O solid-state NMR technique, employed on the highest-field NMR spectrometer in the world (the 36 T Series Connected Hybrid), identifies water molecules in different layers of a model membrane for the first time.
|A Deep Dive Into Forever Chemical Dark Matter||
Using the world's most powerful mass spectrometer, scientists have developed a new method to profile complex PFAS mixtures at the molecular level, facilitating future PFAS characterization in support of environmental and human health studies.
|NMR FAIR Data: Phase-Separation Properties of an RNA-Binding Protein||
Evolutionary biologists reused FAIR data generated at the MagLab's NMR facility to model an RNA-binding protein in mammals dating back 160 million years and to explore how evolution and natural selection have influenced the structure of the protein. Their work suggests new strategies for improving our understanding of this protein, which could lead to improved therapies for neurodegenerative diseases like ALS.
|Atmospheric Carbon Dioxide from Peat Wetland Ecosystems||
Understanding the organic composition of peat wetland soils can determine whether the carbon sources may be converted into carbon dioxide gas, work that could improve existing climate models and better predict the impact of increasing carbon dioxide to wetland ecosystems.
|Imaging Enzyme Active Site Chemistry Using Multiple Fields up to 35.2T||
This new technique for mapping out atom placements in the active site of enzymes could unlock the potential for finding new therapeutics.
|The Blood Proteoform Atlas: A reference map of proteoforms in human blood cells||
A new Blood Proteoform Atlas maps 30,000 unique proteoforms as they appear in 21 different cell types found in human blood. The MagLab's 21 tesla FT-ICR mass spectrometer contributed nearly a third of the atlas' proteoforms.
|Understanding How Fungi Build Their Cell Walls for Protection||
Scientists have used high-field nuclear magnetic resonance (NMR) to reveal how fungal pathogens use carbohydrates and proteins to build their cell walls (the protective layers outside of the cell). These findings will guide the development of novel antifungal drugs that target the cell wall molecules to combat life-threatening diseases caused by invasive fungal infections.
|Restoration of Breathing After Drug Overdose and Spinal Cord Injuries||
Respiratory insufficiency is a leading cause of death due to drug overdose or spinal cord injuries. The diaphragm can be stimulated using temporal interference (TI) to restore ventilation with minimally invasive electrodes.
|A New Method for Understanding Dynamic Nuclear Polarization||
A new method to study how the nuclei of atoms “communicate” with one another in the presence of unpaired electron spins has been developed at the MagLab. Known as hyperpolarization resurgence (HypRes), this method benefits and expands the application of a revolutionary technique known as dynamic nuclear polarization (DNP), which provides enormous signal enhancements in nuclear magnetic resonance (NMR) experiments.