Search results (48)
|Scientists observe molecular movements in T cells||
Insights into the structure and movement of T cell surface proteins could lead to new ways to fight cancers, infections and other diseases.
|Uncovering the secrets of fungal cell walls||
With unprecedented sensitivity and resolution from state-of-the-art magnets, scientists have identified for the first time the cell wall structure of one of the most prevalent and deadly fungi.
|Making a non-heme oxoiron(IV) complex a better oxidant||
This work investigates a series of oxoiron complexes that serve as models towards understanding the mechanism of catalysis for certain iron-containing enzymes.
|Ancient porphyrins indicate far earlier date for photosynthesis||
Molecular fossils of chlorophyll (called porphyrins) more than 1.1 billion years old find suggest that photosynthesis began 600 million years earlier than previously established.
|Imaging pH levels with a Cobalt MRI Probe||
A new pH sensitive contrast agent for MR imaging has been developed that produces image contrast based on the local pH and that has great potential for use in living animals and medical diagnostics.
|Metabolic assessment of migraines using ultra-high magnetic fields||
The causes of migraines are not well understood, with treatment limited to addressing pain rather than its origin. Research conducted with hydrogen MRI is attempting to identify the "migraine generator."
|Imaging current flow in the brain during transcranial electrical stimulation||
Scientists measured the first in vivo images of stimulated current within the brain using an imaging method that may improve reproducibility and safety, and help understand the mechanisms of action of electrical stimulation.
|Novel metallofullerene boosts dynamic nuclear polarization||
In this study, researchers added a low concentration of the endohedral metallofullerene (EMF) Gd2@C79N to DNP samples, finding that 1H and 13C enhancements increased by 40% and 50%, respectively, at 5 teslas and 1.2 Kelvin.
|Targeted annotation of peptides by selective infrared multiphoton dissociation mass spectrometry||
Protein oxidative damage is a common occurrence in a number of diseases, including cancer, neurodegenerative, and cardiovascular disease. Yet, little is known about its contribution to these illnesses. We developed a new technique, utilizing an infrared laser in combination with a mass spectrometer, to selectively identify sites of oxidation in complex protein mixtures. This sensitive and rapid platform may outperform current techniques and thus shed light on the involvement of oxidative damage in each of these diseases.
|Across the Tree of Life: Radiation Resistance Gauged by High-Field EPR||
This high-field EPR study of the H-Mn2+ content in the bacterium Deinococcus Radiodurans provides the strongest known biological indicator of cellular ionizing radiation resistance between and within the three domains of the tree of life, with potential applications including optimization of radiotherapy.