Hannah Shafaat talks about the clever tricks that some strains of tuberculosis may be trying to pull off to resist drugs.
Insights into the structure and movement of T cell surface proteins could lead to new ways to fight cancers, infections and other diseases.
This work investigates a series of oxoiron complexes that serve as models towards understanding the mechanism of catalysis for certain iron-containing enzymes.
In this study, researchers added a low concentration of the endohedral metallofullerene (EMF) Gd2@C79N to DNP samples, finding that 1H and 13C enhancements increased by 40% and 50%, respectively, at 5 teslas and 1.2 Kelvin.
With just a drop of water, a cobalt-based material changes both color and magnetic properties.
A lot of the research conducted in powerful magnets ends up having a powerful effect on our day-to-day lives.
When a grad student's first publication lands in the top-tier journal Nature, you can bet it's not beginner's luck.
Findings published today in Nature may advance the era of quantum computers.
The HiPER spectrometer may not feature the strongest magnet at the MagLab, but it wins hands down in the "coolest looking" category. This powerful tool, from which protrude 29 black, kooky cones, is now open to scientists.
This week at the lab, one of the instrument's first users, biophysicist Brian Hales of Louisiana State University, is here sizing up proteins with the HiPER (pronounced "hyper") spectrometer, which is shorthand for high-power pulsed W-band electron paramagnetic resonance (EPR) .
The "high-power" part refers to the instrument's recently upgraded 1-kilowatt amplifier. Along with other revolutionary design innovations, it makes possible the machine's game-changing sensitivity.
Depending on the technique used with the instrument, this sensitivity is orders of magnitude greater than what was previously available to scientists. This means scientists can run experiments on a material even if they have a just a teeny, tiny bit of it. This capability is extremely significant in structural biology (among other research areas), when scientists might have just a smidgeon of the protein they want to characterize.
"Sensitivity is a major concern," said Likai Song, a research scientist with the lab's Electron Magnetic Resonance Facility who works closely with the 9-tesla HiPER spectrometer. "Improved sensitivity opens the door to a lot of applications."
The instrument is not only expected to be a great boon for scientists like Hales who study proteins, but it will also impact all other research areas in the lab, including material science, physics and chemistry, said Song.
Text by Kristen Coyne. Photo by Stephen Bilenky.
A recent high-field EPR study by MagLab users from Wayne State and Grand Valley State Universities has demonstrated that minor changes in the periphery of a nickel-containing molecule can lead to a dramatic reorganization of its electron distribution. This in turn, induces a major shift in the reactivity of this compound.