Seminar By Phillip Zhe Sun, Emory University

Title: Exploring the Unique Opportunities of Quantitative CEST (QCEST) MRI at Ultra-High Field Strengths

Host: MRI Research Talk Series

Abstract: CEST MRI offers a compelling contrast mechanism to detect dilute metabolites, proteins, and pH changes, which is applicable in imaging for conditions such as acute stroke, cancer, and epilepsy. Despite its potential, most CEST scans have been conducted under non-equilibrium conditions due to time and SAR limitations. Consequently, CEST measurements are highly dependent on RF irradiation schemes, tissue relaxation properties, and field strength, alongside the intrinsic CEST properties, complicating multi-site data harmonization and hindering the progression beyond CEST-weighted imaging. The development of a quasi-steady-state (QUASS) postprocessing analysis presents a promising approach to overcome these challenges. This technique enables rapid CEST MRI scans with manageable SAR (front end) while maintaining quantification accuracy (back end), enhancing sensitivity and precision. Preliminary data from phantoms, animal models, and patients will be presented to demonstrate the capabilities of the emerging quantitative CEST (QCEST) methodology, which stands to benefit greatly from the ultra-high field at MagLab. Future directions for QCEST MRI will be discussed, and feedback is appreciated.

Bio: Phillip Zhe Sun, PhD, is a professor in the Department of Radiology and Imaging Sciences at Emory University School of Medicine. Dr. Sun serves as director of the Imaging Center at Emory National Primate Research Center.