Presentation via Zoom By Lissa Anderson, National MagLab

For Scientists
06/28/2022 2:00 pm - 2:30 pm


Title: Decrypting Biological Codes with ICR

Host: Science Council's MagX Presentation

Discussion Leader: Christopher Hendrickson

Abstract: Nearly all our cells contain the same DNA blueprint, yet humans are a complex amalgamation of ~200 different cell types. Distinctions lie in which genes are ultimately "switched ON" and translated into proteins that operate in the cell; their "proteome". Protein structures and functions are expanded in several ways, including combinations of gene sequence variants, alternative splicing, and post-translational modifications (PTMs). These dictate the distinct molecular "proteoforms" active in cells.

Decrypting proteoform structure-function codes requires instrumentation capable of unequivocally distinguishing nearly identical amino acid sequences while concurrently identifying and site-localizing all PTMs. The MagLab’s 21 T ICR is particularly well equipped to characterize proteoforms in complex mixtures and offers the highest achievable mass resolving power and mass measurement accuracy of any mass analyzer. This talk will describe ways in which high-field ICR is bringing us closer to obtaining truly molecular-level understanding of biological phenomena.

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