Seminar By David Guilfoyle, The Nathan Kline Institute for Psychiatric Research
Title: Exploring the role of N-acetylaspartylglutamate in neurovascular coupling
Host: Jen Rosenberg
Abstract: The exact cellular mechanisms involved in the signaling between neurons and the vascular system, know as neurovascular coupling (NVC), is still unresolved. N-acetyl-L-aspartic acid (NAA) is an amino acid that is present in the vertebrate brain, and in human brain its concentration is among the highest of all free amino acids. N-acetylaspartylglutamate (NAAG) is a dipeptide derivative of NAA and glutamate. This talk will outline our findings at 7T using Magnetic Resonance Imaging and Spectroscopy which suggest that NAAG is a possible coupling mechanism between cerebral blood flow and neuronal activity. The talk will also describe the proposed experiments at 21.1 T at MagLab which we hope will further validate our hypothesis of the role of NAAG in NVC.